MOTS-c Liquid Spray

MOTS-c (Mitochondrial Open-Reading-Frame of the 12S rRNA-c) is a 16-amino-acid peptide encoded within the mitochondrial genome itself — one of the very few peptides known to originate there rather than in nuclear DNA. First characterized at the USC Leonard Davis School of Gerontology in 2015, MOTS-c acts as a mitochondrial hormone, signaling through AMPK and related metabolic pathways to regulate glucose and lipid homeostasis. Real Peptides is the first supplier to offer MOTS-c in liquid spray format — expanding research access beyond traditional injectable-only protocols.

Researchers choose MOTS-c liquid spray when studying mitochondrial-to-nuclear signaling, metabolic syndrome models, insulin resistance, exercise biology, and aging pathways. The pre-solubilized format eliminates reconstitution variability between experiments, supporting consistent concentration control across replicates. Verified ≥99% pure by HPLC with endotoxin <0.1 EU/mg.

MOTS-c is the only widely-studied peptide encoded directly by mitochondrial DNA rather than the nuclear genome. That makes it a uniquely direct biological messenger between cellular energy status and nuclear gene programs — essentially, a molecular signal that bridges the cell’s power plant and its command center. Real Peptides supplies it pre-solubilized in a multi-use format, a presentation with few equivalents currently available for this compound. It’s commonly studied alongside broader mitochondrial and metabolic peptides in energy-metabolism research.