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99% Pure | USA Made | Multi DoseMOTS-c peptide is a 16–amino-acid mitochondrial-derived signaling peptide used in preclinical models to probe energy-metabolism, insulin sensitivity, and cellular stress responses. In cell culture and rodent assays, MOTS-c enhances glucose uptake, modulates AMPK pathways, and supports resilience under metabolic stress. Each 10 mg vial is USA-manufactured, HPLC-verified to ≥ 99% purity, endotoxin-screened (< 0.1 EU/mg), and formulated for laboratory research.
Peptides are not ready to use. Must purchase BAC water for reconstitution.
MOTS-c activates AMPK in myocyte and hepatocyte cultures, modeling enhanced glucose uptake and lipid oxidation.
In rodent insulin-resistance assays, MOTS-c improves insulin signaling markers and glucose-clearance rates.
MOTS-c supports mitochondrial membrane potential and ATP production under oxidative-stress challenges.
Downregulates pro-inflammatory cytokines (TNF-α, IL-6) in macrophage models, offering a tool for inflammation-metabolism crosstalk research.
Upregulates genes associated with cellular repair (PGC-1α, Nrf2) in fibroblast assays, aiding studies of aging and resilience.
Reconstitute MOTS-c in Sterile Water for Injection (SWFI) or Bacteriostatic Water (BAC). Store lyophilized at – 20 °C; keep reconstituted peptide at 2–8 °C for up to 7 days, maintaining ≥ 98% integrity.
MOTS-c (Mitochondrial Open-Reading-Frame of the 12S rRNA-Type c) is a 16–amino-acid peptide encoded within the mitochondrial genome. It acts as a mitochondrial hormone, signaling through AMPK and other metabolic pathways to regulate glucose and lipid homeostasis. In research settings, MOTS-c is applied to cell-culture, organotypic, and in vivo models to explore its role in metabolic health, insulin sensitivity, and cellular stress responses—all without engaging systemic hormone axes.
Researchers choose MOTS-c when they need a precise tool for studying mitochondrial-to-nuclear signaling, energy metabolism, and aging-related pathways. Its ability to trigger AMPK activation and downstream gene programs (PGC-1α, Nrf2) makes it ideal for experiments on metabolic syndrome, type-2 diabetes models, and longevity assays. Manufactured in ISO-certified facilities and verified ≥ 99% pure by HPLC—with endotoxin < 0.1 EU/mg—MOTS-c peptide delivers reproducible, high-fidelity data for cutting-edge metabolic research.
Unlike generic metabolic modulators, MOTS-c is unique as a mitochondrial-derived peptide that directly communicates cellular energy status to nuclear gene programs. Its dual action—enhancing glucose uptake and promoting antioxidant defenses—offers a multi-pathway approach to studying metabolic resilience and aging. With demonstrated stability both lyophilized and in solution, MOTS-c peptide stands out as a next-generation research reagent for dissecting the interplay between mitochondrial health and systemic metabolism.
A 16–amino-acid mitochondrial-derived peptide used to study energy-metabolism, AMPK activation, and insulin sensitivity in research models.
MOTS-c binds cellular targets to trigger AMPK phosphorylation, enhancing glucose uptake and lipid oxidation in cell assays.
Benefits include improved insulin sensitivity, mitochondrial resilience, metabolic regulation, and anti-inflammatory signaling.
In vitro assays often use 100 nM–10 µM, while in vivo rodent studies range 0.1–1 mg/kg.
Yes—rodent insulin-resistance models show enhanced glucose-clearance rates and insulin-signaling markers with MOTS-c treatment.
Dissolve in SWFI or BAC water per protocol, then gently mix until fully solubilized.
Store lyophilized at – 20 °C; keep reconstituted solution at 2–8 °C and use within 7 days.
As a research reagent, MOTS-c shows no systemic side effects but must be handled under standard lab-safety protocols.
Yes—frequently co-studied with mitochondrial or metabolic peptides (e.g., SS-31, NAD⁺) for synergistic energy-metabolism research.
Real Peptides offers ISO-certified, USA-manufactured MOTS-c peptide (10 mg) at ≥ 99% purity and low endotoxin—available for research use only.
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